Using Linkage Map of Mouse for Prediction of Gene Location in Animals

Yasuhiko Wada, Hirohisa Kishino and Nobuhisa Kashiwagi

Dep. Animal Breeding and Genetics
National Institute of Animal Industry
2 Ikenodai, Kukisaki-machi, Inashiki-gun,
Ibaraki 305-0901, Japan

Laboratory of Biometrics
Graduate school of Agricultural and Life Sciences
University of Tokyo
1-1-1, Yayoi, Bunkyo-ku
Tokyo 113-8657, Japan

The Institute of Statistical Mathematics
4-6-7, Minamiazabu, Minato-ku
Tokyo 106-8569, Japan

Summary

  The high-density linkage map of mouse has been constructed. This map
contains quantitative trait loci (QTL) and major genes which are not
mapped on other animals. In this study, a Bayesian model was 
developed to predict the chromosome number of unmapped genes in
animals using comparative mapping data in construct with mouse
linkage map. The comparative mapping data of mouse-human, mouse-rat 
and mouse-cattle is collected from the Animal Genome Database.
In order to examine the accuracy of our method, we randomly divided
the data into two subsets. The ratios of chromosomal translocation
of mouse-human, mouse-rat and mouse-cattle were estimated by one of
the subsets, and the chromosome numbers of mapped genes of human,
rat and cattle were predicted for another subset.

Japanese Journal of Biometrics 20(2), 193-200 (2000)