Analysis of allele segregation distortion in a swine resource family.

Yasue H, Mikawa S, Uenishi H, Wada Y 

Department of Animal Breeding and Genetics, National Institute of
Animal Industry, MAFF, Japan. 

Segregation distortion of alleles was found in several regions of the
genome in allele type analyses of genetic markers for a swine resource
family that had been constructed by crossing Gottingen miniature pig and
Meishan breeds. From these regions, a region on chromosome 6 presented
a distortion over several consecutive markers. This chromosome 6 region
was subsequently further investigated to reveal that alleles of a
chromosome 6 homologue of the Gottingen miniature pig were not found in
a homozygous family member. The litter size of F1-crosses which were
able to produce homozygotes in this region were 24% smaller, on average,
than F1-crosses which were unable to produce homozygotes. This
indicated that this region of the chromosome 6 homologue contained a
recessive gene or genes which could terminate fetal development. An
additional 10 markers were subsequently used to investigate the region
more precisely. These studies revealed that this region spans 7 cM and is
located between markers Sw855 and Sw122. Since current comparative
maps show that this region corresponds to the human chromosome 19
q-arm, genes positioned on the human chromosome 19 q-arm were
screened to select 20 candidate genes. These included the
pregnancy-specific beta-1-glycoprotein
gene.



Anim Biotechnol 1999;10(3):147-52